Khuzistan as a river-plain civilization during pre-Islamic and Islamic era, have had several prosperous cities which in addition to some of the most well-known cities such as Susa, Shushtar and Ahvaz, there were cities which there is no trace of them. Some of these cities which were located adjacent to Karun river were Askar Mokarran, Souq al-Arba’a, Jobai and Dorraq. The main aim of his article is to study the reasons for rise and fall of Khuzistancities during 3^rd and 4^th centuries AH., based on Max Weber’s theory on categorizing cities according to their nature and changes in a descriptive- analytical approach. Our hypothesis is that the existence of several rivers especially the navigable Karun river and its connection with the high seas had been the factor and platform for commercial and cultural formation and prosperous of the Khuzistan cities. According to the findings of this survey, the foundation of the most Khuzistan cities except Asskar Mokarram and Souq al- Arba’a, is dated back to pre-Islamic era. These cities had produced various merchandise and had commercial boom and consequently high cultural development. But these cities had lost their lives over time due to some natural causes such as high water and redirection of the river and also some historical cause such as the effect of Zangi revolt, the emergence of Turks, the change of commercial routs and clash between Arab native powers.